FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.

Effector Cytokine Expression Expression in T Cells Thereby Limiting FOXP3 Inhibits Activation-Induced NFAT2

سلول‌های T تنظیمی: انواع، تولید و عملکرد

T lymphocytes have been characterized to different subsets such as cytotoxic T, Thelper1 (Th1), Th2, Th3, Th9, Th17, and regulatory T cells. Each of these subsets have specific function which distinct them from other lymphocytes. Regulatory T lymphocytes are effective cells in immune system that play an important role in cancers, autoimmune and infectious diseases. Two main subsets of regulator...

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4(+)CD25(+) T regulatory cells (nTregs). In mice, expression of FoxP3 is strictly correlated with regulatory activity, whereas increasing evidence suggests that in humans, activated T effector cells (Teffs) may also express FOXP3. In order to better define the role of FOXP3 in human Teff cells,...

Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2.

NKT cells are unique in that they can produce high levels of both Th1 and Th2 cytokines, yet little is known about how NKT cells control the transcription of Th2 cytokines. The expression of IL-4 by NKT cells is independent of the Th2-associated transcription factor Stat6. We have found that Stat6 is critical for the expression of IL-5, IL-10, and IL-13 by NKT cells. However, the Th2 cell-assoc...

Induction of FOXP3 expression in naive human CD4 FOXP3 T cells by T-cell receptor stimulation is transforming growth factor- –dependent but does not confer a regulatory phenotype

Thymic-derived natural T-regulatory cells (nTregs) are important for the induction of self-tolerance and the control of autoimmunity. Murine CD4 CD25 Foxp3 cells can be induced to express Foxp3 after T-cell receptor (TCR) activation in the presence of transforming growth factor (TGF ) and are phenotypically similar to nTregs. Some studies have suggested that TCR stimulation of human CD4 CD25 ce...